Broadcast on November 19, 1993, this CBS Reports episode blended archival footage and personal recollections to probe the assassination of President Kennedy. "Who Killed JFK?" was a response to a CBS poll that found that 9 out of 10 Americans doubted that Lee Harvey Oswald acted alone and 4 out of 5 believed in some sort of cover-up. The report profiled the suspected assassin, Lee Harvey Oswald, and tested various conspiracy theories. Co-produced by the Washington Post, this program was the sixth large-scale CBS investigation of the Kennedy assassination and leaned this time on Gerald Posner’s conspiracy-debunking book Case Closed. In addition to having been on the site of the assassination, Dan Rather had participated in the 1967 and 1975 extensive studies done by CBS Reports and was, as producers Steve Glauber and Christopher Martin recall, very involved in the preparation of the show.

The Los Angeles Times praised CBS for showing “some class by not mentioning that its weekend-long, commercial-free broadcast of Kennedy's state funeral and burial marked a historic turning point in TV news journalism and for CBS in particular,” but was critical of the show’s quick dismissal of all the key assassination conspiracy theories and its neglect of major unanswered questions, especially those regarding Mafia ties to both Oswald and his killer, Jack Ruby.